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008 120712s2012 xx a ob 001 0 eng d
040 _aDG1
_beng
_cDG1
_dUIU
_dYDXCP
_dOCLCQ
_dCOO
_dOCLCF
_dOCL
_dOCLCQ
_dDEBBG
_dBD-SySUS
020 _a9781118345313
_q(electronic bk.)
020 _a1118345312
_q(electronic bk.)
029 1 _aAU@
_b000049789878
029 1 _aNZ1
_b15900786
029 1 _aDEBBG
_bBV043394764
035 _a(OCoLC)798928650
037 _a10.1002/9781118345313
_bWiley InterScience
_nhttp://www3.interscience.wiley.com
050 1 4 _aQR189
072 7 _aMED
_x071000
_2bisacsh
082 0 4 _a615.3/72
_a615.372
_222
049 _aMAIN
245 0 0 _aVaccinology :
_bprinciples and practice /
_cedited by W. John W. Morrow [and others].
260 _aHoboken :
_bJohn Wiley & Sons,
_c2012.
300 _a1 online resource (554 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aFront Matter -- Introduction. Concept and Scope of Modern Vaccines / D Huw Davies, Clint S Schmidt, Nadeem A Sheikh -- Principles of Vaccine Design. Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants / Heather L Wilson, Scott Napper, George K Mutwiri, Sylvia van Drunen Littel-van den Hurk, Hugh Townsend, Lorne A Babiuk, Andrew A Potter, Volker Gerdts -- Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules / Antony N Antoniou, Izabela Lenart, David B Guiliano, Simon J Powis -- Understanding the Mucosal Immune System for Better Mucosal Vaccine Design / Janine Bilsborough, Joanne L Viney -- Immunologic Memory: T Cells in Humans / Maria Candela Iglesias, Victor Appay, Arnaud Moris -- Immunologic Memory: B cells / F Eun-Hyung Lee, Įaki Sanz -- Utility of Mouse Models in Vaccine Design and Development / Catharine M Bosio, Megan MacLeod, Philippa Marrack, Ross M Kedl -- Utility of Nonhuman Primate Models for Vaccines / Preston A Marx, Alexander F Voevodin -- Antigen Discovery. Sequence-Based Computational Approaches to Vaccine Discovery and Design / Darrick Carter -- Antigen Discovery for Vaccines Using High-Throughput Proteomic Screening Technologies / D Huw Davies -- Phage Libraries / Aaron K Sato -- Antigen Engineering. Attenuated Bacterial Vaccines / Richard W Titball, Helen S Atkins -- Virus-Like Particles as Antigen Scaffolds / Bryce Chackerian, John T Schiller -- Recombinant MVA vaccines: Optimization, Preclinical, and Product Development / Yper Hall, Miles W Carroll -- Recombinant Adenoviruses for Vaccination / Nelson Cesar Di Paolo, Dmitry Shayakhmetov, Andř Lieber -- Recombinant Avipoxviruses / Michael A Skinner, Stephen M Laidlaw -- Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy / Patrick Guirnalda, Laurence Wood, Matthew Seavey, Yvonne Paterson -- Nucleic Acid Vaccination / Britta Wahren, Margaret A Liu -- Artificial Antigen-Presenting Cells: Large Multivalent Immunogens / Matthew F Mescher, Julie M Curtsinger -- Delivery Systems. Transcutaneous Immunization via Vaccine Patch Delivery System / Robert C Seid, Gregory M Glenn -- Needle-Free Jet Injection for Vaccine Administration / Brian R Sloat, Hoi K Tran, Zhengrong Cui -- Oral Vaccines: An Old Need and Some New Possibilities / Amit A Lugade, Kalathil Suresh, Yasmin Thanavala -- Adjuvants: From Serendipity to Rational Discovery / Derek T O'Hagan, Andreas Wack -- Immunostimulatory Properties of Biodegradable Microparticles / Fiona A Sharp, Ed C Lavelle -- Co-Administration of Co-Stimulatory Moieties / Carolina Arancibia-C̀rcamo, Yvette Latchman -- Toll Receptors in Relation to Adjuvant Effects / Dipshikha Chakravortty, Amit Lahiri, Priyanka Das -- Regulatory Considerations. Regulatory Issues (FDA and EMA) / Murrium Ahmad, Victoria Byers, Peter Wilson -- Evaluating Vaccine Efficacy. Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine / Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L Bolton, Camilla Jandus -- Clinical Development Strategy: Nuts and Bolts / Candida Fratazzi, Claudio Carini -- Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification / Robert Rees, Stephanie Laversin, Cliff Murray, Graham Ball -- Implementing Immunizations/Therapies. Mass Immunization Strategies / David L Heymann, R Bruce Aylward, Rudolf H Tangermann -- The Role of Mathematical Models in Vaccine Development and Public Health Decision Making / Marie-Claude Boily, Marc Brisson, Benoit Ḿsse, Roy M Anderson -- Vaccine Safety / John Iskander, Claudia Vellozzi, Jane Gidudu, Robert T Chen -- Index.
520 _aCovering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human applicationIncludes evaluation of vaccine efficacy and safetyDetails clinical trial design, including regulatory requirements.
588 0 _aPrint version record.
650 0 _aVaccines.
650 0 _aDrugs
_xDesign.
650 0 _aVaccination
_xMethods.
650 0 _aMedicine.
650 0 _aPharmacy.
650 7 _aMEDICAL
_xPharmacology.
_2bisacsh
650 7 _aDrugs
_xDesign.
_2fast
_0(OCoLC)fst00898790
650 7 _aMedicine.
_2fast
_0(OCoLC)fst01014893
650 7 _aPharmacy.
_2fast
_0(OCoLC)fst01060285
650 7 _aVaccination.
_2fast
_0(OCoLC)fst01163544
650 7 _aVaccines.
_2fast
_0(OCoLC)fst01163573
655 4 _aElectronic books.
655 7 _aMethods (Music)
_2fast
_0(OCoLC)fst01423850
700 1 _aMorrow, John,
_d1949-
776 0 8 _iPrint version:
_aMorrow, W. John W.
_tVaccinology.
_dHoboken : John Wiley & Sons, 2012
_z9781118345337
_w(OCoLC)795120561
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9781118345313
_zWiley Online Library [Free Download only for SUST IP]
938 _aYBP Library Services
_bYANK
_n9341141
994 _a92
_bDG1
999 _c63526
_d63526