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019 _a809775189
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020 _a9783527664481
_q(electronic bk.)
020 _a3527664483
_q(electronic bk.)
020 _a3527333959
020 _a9783527664450
020 _a3527664459
020 _a9783527333950
020 _a9781283571432
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020 _a1283571439
_q(MyiLibrary)
020 _a9783527664450
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020 _z9783527333950
029 1 _aAU@
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029 1 _aCHBIS
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035 _a(OCoLC)807252111
_z(OCoLC)809775189
_z(OCoLC)811005776
050 4 _aQD400
072 7 _aSCI
_x013040
_2bisacsh
082 0 4 _a547.59
_223
049 _aMAIN
245 0 0 _aBioactive heterocyclic compound classes :
_bpharmaceuticals /
_cedited by Jürgen Dinges and Clemens Lamberth.
260 _aWeinheim :
_bWiley-VCH ;
_aChichester :
_bJohn Wiley [distributor],
_c2012.
300 _a1 online resource (xv, 356 pages)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
588 0 _aPrint version record.
520 _aThis volume presents important pharmaceuticals. Each of the around 20 chapters covers in a concise manner one class of heterocycles, clearly structured as follows:* Structural formulas of most important examples (market products)* Short background of history or discovery* Typical syntheses of important examples* Mode of action* Characteristic biological activity* Structure-activity relationship* Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.)* References. A valuable one-stop reference source for researchers in academia and industr.
650 0 _aHeterocyclic compounds.
650 0 _aPharmaceutical chemistry.
650 7 _aSCIENCE
_xChemistry
_xOrganic.
_2bisacsh
650 7 _aHeterocyclic compounds.
_2fast
_0(OCoLC)fst00955736
650 7 _aPharmaceutical chemistry.
_2fast
_0(OCoLC)fst01060115
655 4 _aElectronic books.
700 1 _aLamberth, Clemens.
700 1 _aDinges, Jurgen.
776 0 8 _iPrint version:
_tBioactive heterocyclic compound classes.
_dWeinheim : Wiley-VCH ; Chichester : John Wiley [distributor], 2012
_z9783527333950
_w(OCoLC)807249672
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9783527664450
_zWiley Online Library [Free Download only for SUST IP]
880 0 _6505-00/(S
_aIntroduction. The significance of heterocycles for pharmaceuticals and agrochemicals / Clemens Lamberth, Jürgen Dinges -- Neurological disorders. Tropane-based alkaloids as muscarinic antagonists for the treatment of asthma, obstructive pulmonary disease, and motion sickness / Michael L Schulte, Craig W Lindsley ; Morphinone-based opioid receptor agonist analgesics / Stephanie M Ng ; Barbituric acid-based GABA(A) receptor modulators for the treatment of sleep disorder and epilepsy and as anesthetics / Ingo Janser, Romy Janser ; Phenothiazine-based dopamine D antagonists for the treatment of schizophrenia / Cristiana A Zaharia ; Arylpiperazine-based 5-HT receptor partial agonists and 5-HT antagonists for the treatment of autism, depression, anxiety, psychosis, and schizophrenia / Irini Akritopoulou-Zanze ; Arylpiperidine-based dopamine D antagonists/5-HT antagonists for the treatment of autism, depression, schizophrenia, and bipolar disorder / Ying Wang ; Dibenzazepine-based sodium channel blockers for the treatment of neuropathic pain / Derek W Nelson -- Cardiovascular diseases. Dihydropyridine-based calcium channel blockers for the treatment of angina pectoris and hypertension / Milan Bruncko ; Tetrazole-based angiotensin II type 1 (AT) antagonists for the treatment of heart failure and congestive hypertension / Edward C Lawson, Brian C Shook, James C Lanter ; Thiazide-based diuretics for the treatment of hypertension and genitourinary disorders / Jürgen Dinges ; Tetrahydropyranone-based HMG-CoA reductase inhibitors for the treatment of arterial hypercholesterolemia / Hongyu Zhao -- Infectious diseases. Adenine-based reverse transcriptase inhibitors as anti-HIV agents / Alastair Donald ; Guanine-based nucleoside analogs as antiviral agents / Maurizio Franzini ; Penicillin and cephalosporin antibiotics / Michael Z Hoemann -- Oncology. Pyrimidine-based kinase inhibitors in cancer chemotherapy / Robert Mah ; Benzyl triazole-based aromatase inhibitors for the treatment of breast cancer / Dawn George, Stacy Van Epps -- Inflammation and gastrointestinal diseases. Acetonide-based glucocorticoids for the treatment of asthma, skin inflammation, and diseases of the eye / Kevin P Cusack, Vikram G Kalthod, Rajarathnam E Reddy, Sanjay R Chemburkar ; Benzimidazole-based H/K-ATPase inhibitors for the treatment of gastroesophageal reflux disease / Steve Swann -- Metabolic diseases. Thiazolidinedione-based insulin sensitizers: PPAR-γ agonists for the treatment of type 2 diabetes / Steven Richards -- Index.
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