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_a612.8/2 _223 |
| 049 | _aMAIN | ||
| 245 | 0 | 0 |
_aCyclic-nucleotide phosphodiesterases in the central nervous system : _bfrom biology to drug discovery / _cedited by Nicholas J. Brandon, Anthony R. West. |
| 264 | 1 |
_aHoboken, New Jersey : _bJohn Wiley & Sons, Inc., _c[2014] |
|
| 300 |
_a1 online resource (xi, 386 pages) : _billustrations (some color). |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 490 | 1 | _aWiley series in drug discovery and development | |
| 504 | _aIncludes bibliographical references. | ||
| 505 | 0 | _aPhosphodiesterases and cyclic nucleotide signaling in the CNS / Marco Conti and Wito Richter -- Putting together the pieces of phosphodiesterase distribution patterns in the brain : a jigsaw puzzle of cyclic nucleotide regulation / Michy P. Kelly -- Compartmentalization and regulation of cyclic nucleotide signalling in the CNS / Manuela Zaccolo and Alessandra Stangherlin -- Pharmacological manipulation of cyclic nucleotide phosphodiesterase signaling for the treatment of neurological and psychiatric disorders in the brain / Frank S. Menniti, Niels Plath, Christopher J. Schmidt, and Niels Svenstrup -- Recent results in phosphodiesterase inhibitor development and CNS applications / David P. Rotella -- Crystal structures of phosphodiesterases and implication on discovery of inhibitors / Hengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang -- Inhibition of cyclic nucleotide phosphodiesterases to regulate memory / Han-Ting Zhang, Ying Xu, James O'Donnell -- Emerging role for PDE4 in neuropsychiatric disorders : translating advances from genetic studies into relevant therapeutic strategies / Sandra P. Zoubovsky, Nicholas J. Brandon P, and Akira Sawa -- Beyond erectile dysfunction : understanding PDE5 activity in the central nervous system / Eva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W Steinbusch, and Jos Prickaerts -- Molecular and cellular understanding of PDE10A : a dual-substrate phosphodiesterase with therapeutic potential to modulate basal ganglia function / Erik I. Charych and Nicholas J. Brandon -- Role of cyclic nucleotide signaling and phosphodiesterase activation in the modulation of electrophysiological activity of central neurons / Sarah Threlfell and Anthony R. West -- The role of phosphodiesterases in dopamine systems governing motivated behavior / Gretchen L. Snyder, Akinori Nishi, and Joseph P. Hendrick -- Inhibition of phosphodiesterases as a strategy for treatment of spinal cord injury / Elena Nikulina and Marie T. Filbin. | |
| 588 | 0 | _aPrint version record and CIP data provided by publisher. | |
| 650 | 0 | _aCyclic nucleotide phosphodiesterases. | |
| 650 | 0 |
_aCentral nervous system _xPhysiology. |
|
| 650 | 0 | _aNucleotides, Cyclic. | |
| 650 | 2 |
_a3',5'-Cyclic-AMP Phosphodiesterases _xmetabolism. |
|
| 650 | 2 |
_a3',5'-Cyclic-AMP Phosphodiesterases _xtherapeutic use. |
|
| 650 | 2 |
_aCentral Nervous System _xphysiology. |
|
| 650 | 2 |
_aCentral Nervous System Diseases _xdrug therapy. |
|
| 650 | 2 | _aDrug Discovery. | |
| 650 | 7 |
_aMEDICAL _xPhysiology. _2bisacsh |
|
| 650 | 7 |
_aSCIENCE _xLife Sciences _xHuman Anatomy & Physiology. _2bisacsh |
|
| 650 | 7 |
_aCentral nervous system. _2fast _0(OCoLC)fst00850724 |
|
| 650 | 7 |
_aCyclic nucleotide phosphodiesterases. _2fast _0(OCoLC)fst00885846 |
|
| 655 | 4 | _aElectronic books. | |
| 655 | 0 | _aElectronic books. | |
| 700 | 1 |
_aBrandon, Nicholas J., _eeditor. |
|
| 700 | 1 |
_aWest, Anthony R., _d1970- _eeditor. |
|
| 776 | 0 | 8 |
_iPrint version: _tCyclic-nucleotide phosphodiesterases in the central nervous system. _dHoboken, New Jersey : John Wiley & Sons, Inc., [2014] _z9780470566688 _w(DLC) 2013042742 _w(OCoLC)861755359 |
| 830 | 0 | _aWiley series in drug discovery and development. | |
| 856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118836507 _zWiley Online Library [Free Download only for SUST IP] |
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