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035 _a(OCoLC)868315167
_z(OCoLC)867818476
_z(OCoLC)961641712
_z(OCoLC)962636120
037 _a560350
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050 4 _aQD262
072 7 _aSCI
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082 0 4 _a547.2
_223
049 _aMAIN
245 0 0 _aCopper-catalyzed asymmetric synthesis /
_cedited by Alexandre Alexakis, Norbert Krause, Simon Woodward.
264 1 _aWeinheim :
_bWiley-VCH,
_c2014.
300 _a1 online resource (xvi, 454 pages) :
_billustrations
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
588 0 _aPrint version record.
505 0 _a1. The primary organometallic in copper-catalyzed reactions / Simon Woodward -- 2. Copper-catalyzed asymmetric conjugate addition / Alexandre Alexakis, Norbert Krause and Simon Woodward -- 3. Copper-catalyzed asymmetric conjugate addition and allylic substitution of organometallic reagents to extended multiple-bond systems / Matthieu Tis sot, Hailing Li and Alexandre Alexakis -- 4. Asymmetric allylic alkylation / Olivier Baslé, Audrey Denicourt-Nowicki, Christopohe Crévisy and Marc Mauduit -- 5. Ring opening of epoxides and related systems / Mauro Pineschi -- 6. Carbon-boron and carbon-silicon bond formation / Masaya Sawamura and Hajime Ito -- 7. CuH in asymmetric reductions / Bruce H. Lipshutz -- 8. Asymmetric cyclopropanation and aziridination reactions / André B. Charette, Hélène Lebel and Marie-Noelle Roy -- 9. Copper-catalyzed asymmetric addition reaction of imines / Kiyoshi Tomioka, Ken-ichi Yamada and Yasutomo Yamamoto -- 10. Carbometallation reactions / Dorian Didier and Ilan Marek -- 11. Chiral copper Lewis acids in asymmetric transformations / Shinya Adachi, Ramkumar Moorthy and Mukund P. Sibi -- 12. Mechanistic aspects of copper-catalyzed reactions / Per-Fredrik Larsson, Per-Ola Norrby and Simon Woodward -- 13. NMR spectroscopic aspects / Felicitas von Rekowski, Carina Koch and Ruth M. Gschwind -- 14. Application to the synthesis of natural products / Beatriz C. Calvo, Jeffrey Buter and Adriaan J. Minnaard.
520 3 _aThis book reflects the increasing interest among the chemical synthetic community in the area of asymmetric copper-catalyzed reactions, and introduces readers to the latest, most significant developments in the field. The contents are organized according to reaction type and cover mechanistic and spectroscopic aspects as well as applications in the synthesis of natural products. A whole chapter is devoted to understanding how primary organometallics interact with copper to provide selective catalysts for allylic substitution and conjugate addition, both of which are treated in separate chapters. Another is devoted to the variety of substrates and experimental protocols, while an entire chapter covers the use on non-carbon nucleophiles. Other chapters deal with less-known reactions, such as carbometallation or the additions to imines and related systems, while the more established reactions cyclopropanation and aziridination as well as the use of copper (II) Lewis acids are warranted their own special chapters. Two further chapters concern the processes involved, as determined by mechanistic studies. Finally, a whole chapter is devoted to the synthetic applications. This book is essential reading for researchers at academic institutions and professionals at pharmaceutical or agrochemical companies.
504 _aIncludes bibliographical references at the end of each chapters and index.
650 0 _aAsymmetric synthesis.
650 0 _aCopper catalysts.
650 0 _aOrganocopper compounds.
650 0 _aOrganic compounds
_xSynthesis.
650 7 _aSCIENCE
_xChemistry
_xOrganic.
_2bisacsh
650 7 _aAsymmetric synthesis.
_2fast
_0(OCoLC)fst00819861
650 7 _aCopper catalysts.
_2fast
_0(OCoLC)fst00878447
650 7 _aOrganic compounds
_xSynthesis.
_2fast
_0(OCoLC)fst01047668
650 7 _aOrganocopper compounds.
_2fast
_0(OCoLC)fst01047934
655 4 _aElectronic books.
655 0 _aElectronic books.
700 1 _aAlexakis, Alexandre,
_eeditor.
700 1 _aKrause, Norbert,
_eeditor.
700 1 _aWoodward, Simon
_c(Professor of Synthetic Organic Chemistry),
_eeditor.
776 0 8 _iPrint version:
_tCopper-catalyzed asymmetric synthesis
_z9783527332045
_w(OCoLC)862092543
856 4 0 _uhttp://onlinelibrary.wiley.com/book/10.1002/9783527664573
_zWiley Online Library [Free Download only for SUST IP]
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