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007			cr |||||||||||
008			140702s2014 enk ob 001 0 eng
010			_a 2014026252
040			_aDLC _beng _erda _cDLC _dDG1 _dYDXCP _dN$T _dIDEBK _dOCLCF _dCOO _dTEFOD _dRECBK _dOCLCO _dTEFOD _dEBLCP _dOCLCQ _dDEBBG _dBD-SySUS
019			_a904024916
020			_a9781118763100 _qelectronic bk.
020			_a1118763106 _qelectronic bk.
020			_z9781118763094
020			_z1118763092
020			_z9781119979661 (cloth)
020			_z9781118763070
020			_z1118763076
020			_z1119979668
020			_z9781322776293
020			_z1322776296
028	0	1	_aEB00593999 _bRecorded Books
029	1		_aCHBIS _b010442316
029	1		_aCHVBK _b334088925
029	1		_aNZ1 _b15913643
029	1		_aCHVBK _b338338918
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029	1		_aDEBBG _bBV042792720
029	1		_aDEBBG _bBV043396955
035			_a(OCoLC)882620442 _z(OCoLC)904024916
037			_aA025133C-1E63-4589-BDA2-4D7FED6A46F7 _bOverDrive, Inc. _nhttp://www.overdrive.com
042			_apcc
050	0	0	_aR853.C55
060	1	0	_aQV 771
072		7	_aMED _x071000 _2bisacsh
082	0	0	_a615.5072/4 _223
049			_aMAIN
245	0	0	_aStatistical methods for evaluating safety in medical product development / _ceditor Lawrence Gould, Merck Research Laboratories, USA.
264		1	_aChichester, West Sussex, UK : _bWiley, _c2014.
300			_a1 online resource.
336			_atext _2rdacontent
337			_acomputer _2rdamedia
338			_aonline resource _2rdacarrier
490	1		_aStatistics in practice
504			_aIncludes bibliographical references and index.
505	0		_aSafety graphics / A. Lawrence Gould -- QSAR modeling : prediction of biological activity from chemical structure / Andy Liaw and Vladimir Svetnik -- Ethical and practical issues in phase I trials in healthy volunteers / Stephen Senn -- Phase I trials / A. Lawrence Gould -- Summarizing adverse event risk / A. Lawrence Gould -- Statistical analysis of recurrent adverse events / Liqun Diao, Richard J. Cook, and Ker-Ai Lee -- Cardiovascular toxicity, especially QT/QTc prolongation / Arne Ring and Robert Schall -- Hepatic toxicity / Donald C. Trost -- Neurotoxicity / A. Lawrence Gould -- Safety monitoring / Jay Herson -- Sequential testing for safety evaluation / Jie Chen -- Evaluation of post-marketing safety using spontaneous reporting databases / Ismail Ahmed, Bernard Begaud, and Pascale Tubert-Bitter / Pharmacovigilance using observational/longitudinal databases and web-based information / A. Lawrence Gould.
588			_aDescription based on print version record and CIP data provided by publisher.
520			_aThis book gives professionals in clinical research valuable information on the challenging issues of the design, execution, and management of clinical trials, and how to resolve these issues effectively. It also provides understanding and practical guidance on the application of contemporary statistical methods to contemporary issues in safety evaluation during medical product development. Each chapter provides sufficient detail to the reader to undertake the design and analysis of experiments at various stages of product development, including comprehensive references to the relevant literature. -Provides a guide to statistical methods and application in medical product development -Assists readers in undertaking design and analysis of experiments at various stages of product development -Features case studies throughout the book, as well as, SAS and R code.
650		2	_aDrug Evaluation _xmethods.
650		2	_aClinical Trials as Topic.
650		2	_aModels, Statistical.
650		2	_aPharmacovigilance.
650		2	_aSafety Management _xmethods.
650		2	_aTechnology, Pharmaceutical _xstandards.
650		0	_aClinical trials _xStatistical methods.
650		7	_aMEDICAL _xPharmacology. _2bisacsh
650		7	_aClinical trials _xStatistical methods. _2fast _0(OCoLC)fst00864440
650		4	_aMedical.
655		4	_aElectronic books.
700	1		_aGould, Lawrence _q(A. Lawrence), _eeditor.
776	0	8	_iPrint version: _tStatistical methods for evaluating safety in medical product development _dChichester, West Sussex, United Kingdom ; Hoboken : John Wiley & Sons Inc., 2014 _z9781119979661 _w(DLC) 2014025599
830		0	_aStatistics in practice.
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9781118763070 _zWiley Online Library [Free Download only for SUST IP]
938			_aEBSCOhost _bEBSC _n943104
938			_aIngram Digital eBook Collection _bIDEB _ncis30551307
938			_aYBP Library Services _bYANK _n10706429
938			_aYBP Library Services _bYANK _n12261973
938			_aRecorded Books, LLC _bRECE _nrbeEB00593999
938			_aEBL - Ebook Library _bEBLB _nEBL4038476
994			_a92 _bDG1
999			_c65060 _d65060