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_a615.1/9 _223 |
| 049 | _aMAIN | ||
| 245 | 0 | 0 |
_aSuccessful drug discovery / _cedited by János Fischer and David P. Rotella. |
| 264 | 1 |
_aWeinheim, Germany : _bWiley-VCH, _c2015. |
|
| 300 | _a1 online resource. | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 505 | 0 | _aPart I: General Aspects. Serendipitous Target-Based Drug Discoveries / János Fischer, David P Rotella -- Drug Discoveries and Molecular Mechanism of Action / David C Swinney -- Part II: Drug Class. Insulin Analogs -- Improving the Therapy of Diabetes / John M Beals -- Part III: Case Histories. The Discovery of Stendra (Avanafil) for the Treatment of Erectile Dysfunction / Koichiro Yamada, Toshiaki Sakamoto, Kenji Omori, Kohei Kikkawa -- Dapagliflozin, A Selective SGLT2 Inhibitor for Treatment of Diabetes / William N Washburn -- Elvitegravir, A New HIV-1 Integrase Inhibitor for Antiretroviral Therapy / Hisashi Shinkai -- Discovery of Linagliptin for the Treatment of Type 2 Diabetes Mellitus / Matthias Eckhardt, Thomas Klein, Herbert Nar, Sandra Thiemann -- The Discovery of Alimta (Pemetrexed) / Edward C Taylor -- Perampanel: A Novel, Noncompetitive AMPA Receptor Antagonist for the Treatment of Epilepsy / Shigeki Hibi -- Discovery and Development of Telaprevir (Incivek): A Protease Inhibitor to Treat Hepatitis C Infection / Bhisetti G Rao, Mark Murcko, Mark J Tebbe, Ann D Kwong -- Antibody-Drug Conjugates: Design and Development of Trastuzumab Emtansine (T-DM1) / Sandhya Girish, Gail D Lewis Phillips, Fredric S Jacobson, Jagath R Junutula, Ellie Guardino. | |
| 504 | _aIncludes bibliographical references and index. | ||
| 588 | 0 | _aOnline resource; title from PDF title page (John Wiley, viewed February 23, 2015). | |
| 520 | _aThe first volume of the book series "Successful Drug Discovery" is focusing on new drug discoveries during the last decade, from established drugs to recently introduced drugs of all kinds:small-molecule-, peptide-, and protein-based drugs. The role of serendipity is analyzed in some very successful drugs where the research targets of the lead molecule and the drug are different. Phenotypic and target-based drug discovery approaches are discussed from the viewpoint of pioneer drugs and analogues. This volume gives an excellent overview of insulin analogues including a discussion of the properties of rapid-acting andlong-acting formulations of this important hormone. The major part of the book is devoted to case histories of new drug discoveries described by their key inventors. Eight case histories range across many therapeutic fields. The goal of this book series is to help the participants of thedrug research community with a reference book series and to support teaching in medicinal chemistry with case histories and review articles of new drugs. | ||
| 650 | 0 |
_aDrugs _xDesign. |
|
| 650 | 0 | _aPharmaceutical chemistry. | |
| 650 | 4 | _aMedical. | |
| 650 | 7 |
_aMEDICAL _xPharmacology. _2bisacsh |
|
| 650 | 7 |
_aDrugs _xDesign. _2fast _0(OCoLC)fst00898790 |
|
| 650 | 7 |
_aPharmaceutical chemistry. _2fast _0(OCoLC)fst01060115 |
|
| 655 | 4 | _aElectronic books. | |
| 700 | 1 |
_aFischer, János, _eeditor. |
|
| 700 | 1 |
_aRotella, David P., _eeditor. |
|
| 776 | 0 | 8 |
_iPrint version: _z9783527678433 _w(OCoLC)903897512 |
| 856 | 4 | 0 |
_uhttp://onlinelibrary.wiley.com/book/10.1002/9783527678433 _zWiley Online Library [Free Download only for SUST IP] |
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