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008			150307s2015 gw ob 001 0 eng d
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019			_a909907512 _a953987850 _a960203676 _a961625844 _a962626284
020			_a9783527673643 _q(electronic bk.)
020			_a3527673644 _q(electronic bk.)
020			_a9783527673674 _q(electronic bk.)
020			_a3527673679 _q(electronic bk.)
020			_z9783527673667
020			_z3527673660
020			_z9783527335114
020			_z3527335110
029	1		_aCHDSB _b006359936
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029	1		_aDEBBG _bBV042792550
029	1		_aDEBBG _bBV043397595
035			_a(OCoLC)904518353 _z(OCoLC)909907512 _z(OCoLC)953987850 _z(OCoLC)960203676 _z(OCoLC)961625844 _z(OCoLC)962626284
050		4	_aRS420
072		7	_aMED _x071000 _2bisacsh
082	0	4	_a615.19 _223
049			_aMAIN
245	0	0	_aAntitargets and drug safety / _cedited by Laszlo Urban, Vinod F. Patel and Roy J. Vaz.
260			_aWeinheim : _bWiley-VCH, _c2015.
300			_a1 online resource (1266 pages).
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
490	1		_aMethods and principles in medicinal chemistry ; _vv. 66
504			_aIncludes bibliographical references and index.
588	0		_aPrint version record.
505	0		_aGeneral Concept for Target-based Safety Assessment. Side Effects of Marketed Drugs: The Utility and Pitfalls of Pharmacovigilance / Steven Whitebread, Mateusz Maciejewski, Alexander Fekete, Eugen Lounkine, László Urbán -- Prediction of Drug Side Effects / Michael J Keiser -- Translational Value of Preclinical Safety Assessment: System Organ Class (SOC) Representation of Off-Targets / Mateusz Maciejewski, Eugen Lounkine, Andreas Hartmann, Steven Whitebread, László Urbán -- Pathological Conditions Associated with the Disturbance of the 5-HT System / Daniel Hoyer -- Hepatic Side Effects. Drug-Induced Liver Injury: Clinical and Diagnostic Aspects / John R Senior -- Mechanistic Safety Biomarkers for Drug-Induced Liver Injury / Daniel J Antoine -- Models for the Prediction of Drug-Induced Liver Injury in Lead Discovery / Frederic Moulin, Oliver Flint -- Transporters in the Liver / Bruno Stieger, Gerd A Kullak-Ublick -- Mechanistic Modeling of Drug-Induced Liver Injury (DILI) / Kyunghee Yang, Jeffrey L Woodhead, Lisl K Shoda, Yuching Yang, Paul B Watkins, Kim LR Brouwer, Brett A Howell, Scott Q Siler -- Cardiovascular Side Effects. Functional Cardiac Safety Evaluation of Novel Therapeutics / Jean-Pierre Valentin, Brian Guth, Robert L Hamlin, Pierre Lainée, Dusty Sarazan, Matt Skinner -- Safety Aspects of the Ca1.2 Channel / Berengere Dumotier, Martin Traebert -- Cardiac Sodium Current (Na1.5) / Gary Gintant -- Circulating Biomarkers for Drug-Induced Cardiotoxicity: Reverse Translation from Patients to Nonclinical Species / Gül Erdemli, Haisong Ju, Sarita Pereira -- The Mechanistic Basis of hERG Blockade and the Proarrhythmic Effects Thereof / Robert A Pearlstein, K Andrew MacCannell, Qi-Ying Hu, Ramy Farid, José S Duca -- Kinase Antitargets. Introduction to Kinase Antitargets / Mark C Munson -- Clinical and Nonclinical Adverse Effects of Kinase Inhibitors / Douglas A Keller, Richard J Brennan, Karen L Leach -- Cardiac Side Effects Associated with Kinase Proteins and Their Signaling Pathways / Roy J Vaz, Vinod F Patel -- Case Studies: Selective Inhibitors of Protein Kinases : Exploiting Demure Features / Ellen R Laird -- Examples of Clinical Translation. Torcetrapib and Dalcetrapib Safety: Relevance of Preclinical and Models / Eric J Niesor, Andrea Greiter-Wilke, Lutz Müller -- Targets Associated with Drug-Related Suicidal Ideation and Behavior / Andreas Hartmann, Steven Whitebread, Jacques Hamon, Alexander Fekete, Christian Trendelenburg, Patrick Y Müller, László Urbán.
520			_aWith its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing.
650		0	_aDrug development.
650		0	_aDrugs _xDesign.
650		0	_aDrugs _xSide effects.
650		0	_aDrug interactions.
650		4	_aDrug development.
650		4	_aDrugs _xDesign.
650		4	_aMedicine.
650		7	_aMEDICAL _xPharmacology. _2bisacsh
650		7	_aDrug development. _2fast _0(OCoLC)fst00898670
650		7	_aDrug interactions. _2fast _0(OCoLC)fst00898681
650		7	_aDrugs _xDesign. _2fast _0(OCoLC)fst00898790
650		7	_aDrugs _xSide effects. _2fast _0(OCoLC)fst00898912
655		4	_aElectronic books.
700	1		_aUrbán, László.
700	1		_aPatel, Vinod F.
700	1		_aVaz, Roy J.
776	0	8	_iPrint version: _aUrban, Laszlo. _tAntitargets and Drug Safety. _dHoboken : Wiley, ©2015 _z9783527335114
830		0	_aMethods and principles in medicinal chemistry ; _vv. 66.
856	4	0	_uhttp://onlinelibrary.wiley.com/book/10.1002/9783527673643 _zWiley Online Library [Free Download only for SUST IP]
938			_aCoutts Information Services _bCOUT _n31158518
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938			_aebrary _bEBRY _nebr11048186
938			_aEBSCOhost _bEBSC _n981374
938			_aIngram Digital eBook Collection _bIDEB _ncis31158518
938			_aRecorded Books, LLC _bRECE _nrbeEB00597802
938			_aYBP Library Services _bYANK _n12326969
938			_aYBP Library Services _bYANK _n12409935
938			_aYBP Library Services _bYANK _n11419842
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