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| 003 | BD-SySUS | ||
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| 006 | m o d | ||
| 007 | cr cnu|||unuuu | ||
| 008 | 190607t20192019enk ob 001 0 eng d | ||
| 020 |
_a9780128139400 _q(electronic bk.) |
||
| 020 |
_a0128139404 _q(electronic bk.) |
||
| 020 | _z9780128139394 | ||
| 020 | _a0128139390 | ||
| 020 | _a9780128139394 | ||
| 035 |
_a(OCoLC)1103918307 _z(OCoLC)1229507269 _z(OCoLC)1235837465 |
||
| 040 |
_aN$T _beng _erda _epn _cN$T _dEBLCP _dN$T _dOPELS _dOCLCF _dUKMGB _dUKAHL _dOCLCQ _dERF _dLVT _dUX1 _dVT2 _dOCLCO |
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| 050 | 4 | _aRM301.3.G45 | |
| 060 | 0 | 0 | _a2019 G-375 |
| 060 | 1 | 0 | _aQV 38.5 |
| 072 | 7 | _aMED | |
| 082 | 0 | 4 |
_a615.7 _223 |
| 100 | 1 |
_aCacabelos, R. _q(Ramón), _d1955- _eauthor. _963836 |
|
| 245 | 1 | 0 |
_aPharmacoepigenetics / _cRamón Cacabelos. |
| 250 | _aFirst edition. | ||
| 264 | 1 |
_aLondon : _bAcademic Press, an imprint of Elsevier, _c[2019] |
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| 264 | 4 | _c©2019 | |
| 300 | _a1 online resource | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 490 | 1 |
_aTranslational epigenetics series ; _vvolume 10 |
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| 504 | _aIncludes bibliographical references and index. | ||
| 505 | 0 | _aFront Cover; Pharmacoepigenetics; Copyright; Contents; Contributors; Pharmacoepigenetics: A Long Way Ahead; Chapter 1: The Epigenetic Machinery in the Life Cycle and Pharmacoepigenetics; 1.1. Introduction; 1.2. The Epigenetic Machinery; 1.2.1. DNA Methylation; 1.2.2. DNA Demethylation; 1.2.2.1. Ten-Eleven Translocation (TET) Proteins; 1.2.2.2. AID/APOBEC Family Cytidine Deaminases; 1.2.2.3. BER (Base Excision Repair) Glycosylases; 1.2.3. Chromatin Remodeling and Histone Modifications; 1.2.3.1. Chromatin; 1.2.3.1.1. Genome-Wide Chromatin Conformation, Spatial Organization, and 3D Genomics | |
| 505 | 8 | _a1.2.3.2. Histones1.2.3.3. Posttranslational Modifications; 1.2.3.3.1. Histone Methylation-Demethylation; 1.2.3.3.2. Histone Acetylation; 1.2.3.3.3. Histone Deacetylation; Sirtuins; 1.2.3.3.4. Histone Acylation; 1.2.3.3.5. Histone Propionylation; 1.2.3.3.6. N-Glycosylation and O-GlcNAcylation; 1.2.3.3.7. Ubiquitination-Deubiquitination; 1.2.3.3.8. SUMOylation; 1.2.3.3.9. Histone Phosphorylation-Dephosphorylation; 1.2.3.3.10. Histone Chaperonization; 1.2.3.3.11. Glutathionylation; 1.2.3.3.12. Poly ADP-Ribosylation; 1.2.3.3.13. Oxidative Stress; 1.2.3.4. Other Posttranslational Changes | |
| 505 | 8 | _a1.2.3.5. Noncoding RNAs1.2.3.5.1. miRNAs; 1.2.3.5.2. circRNAs; 1.2.3.5.3. RNA Methylation; 1.2.3.6. Other Operational Elements of the Epigenetic Machinery; 1.2.3.6.1. DNA Replication Regulators; 1.2.3.6.2. N6-Adenine DNA Methylation; 1.2.3.6.3. Transcription Factors; 1.2.3.6.4. Transcriptional Repression; 1.2.3.6.5. Polycomb Group Proteins: Polycomb Repressive Complex 2 (PRC2); 1.2.3.6.6. BET (Bromodomain and Extraterminal Domain) Proteins; 1.2.3.6.7. UHRF1; 1.2.3.6.8. Plant Homeodomain (PHD) Fingers; 1.2.3.6.9. HDACs; 1.2.3.6.10. Chromatin-Remodeling Factors | |
| 505 | 8 | _a1.2.3.6.11. Heterochromatin and Gene Silencing1.2.3.6.12. MEN1; 1.2.3.6.13. NPC, HOXA, and Nup93; 1.2.3.6.14. CCR4; 1.2.3.6.15. HP1; 1.2.3.6.16. TORC1; 1.2.3.6.17. WDR5; 1.2.3.6.18. Nudt21; 1.2.3.6.19. Trithorax-Group Proteins; 1.2.3.6.20. SUUR Protein; 1.2.3.6.21. Kap123; 1.2.3.6.22. SET Complex; 1.2.3.6.23. Histone Code Reader Spin1; 1.2.3.6.24. Proteasome; 1.2.3.6.25. Lipid Mediators; 1.2.3.6.26. Transposable Elements; 1.2.3.6.27. Intragenic Enhancers; 1.2.3.6.28. Genomic Regulatory Regions; 1.3. Singular Epigenetic Phenomena; 1.3.1. Aneuploidy; 1.3.2. X Chromosome Inactivation | |
| 505 | 8 | _a1.3.3. Meiotic Silencing1.3.4. RNA Splicing; 1.3.5. Copy Number Variation (CNV); 1.3.6. The Epigenetic Clock; 1.3.7. Epigenetic Reprogramming Memory; 1.3.8. Transgenerational Epigenetic Inheritance; 1.3.9. DNA Repair Pathways and Genomic Instability; 1.3.10. Antibody Maturation; 1.3.11. Sexual Dimorphism; 1.3.12. Heritable RNAi; 1.3.13. Genomic Imprinting; 1.4. Evolution; 1.5. Population Epigenetics; 1.6. Fertility and Gestation; 1.6.1. In Vitro Fertilization and Assisted Reproduction Technology; 1.7. Placenta; 1.8. Lactation; 1.9. Development; 1.10. Maturation, Aging, and Longevity | |
| 588 | 0 | _aOnline resource; title from PDF title page (EBSCO, viewed June 10, 2019). | |
| 650 | 0 |
_aPharmacogenetics. _963837 |
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| 650 | 0 |
_aPharmacogenomics. _963838 |
|
| 650 | 0 |
_aEpigenetics. _963839 |
|
| 650 | 7 |
_aMEDICAL _xPharmacology. _2bisacsh _963840 |
|
| 650 | 7 |
_aEpigenetics. _2fast _0(OCoLC)fst01893642 _963841 |
|
| 650 | 7 |
_aPharmacogenetics. _2fast _0(OCoLC)fst01060243 _963842 |
|
| 650 | 7 |
_aPharmacogenomics. _2fast _0(OCoLC)fst01060245 _963843 |
|
| 650 | 1 | 2 |
_aPharmacogenetics. _963844 |
| 650 | 2 | 2 |
_aEpigenomics. _963845 |
| 650 | 2 | 2 |
_aEpigenesis, Genetic. _963846 |
| 830 | 0 |
_aTranslational epigenetics series ; _vv. 10. _963847 |
|
| 856 | 4 | 0 |
_3ELSEVIER _uhttps://www.sciencedirect.com/science/book/9780128139394 |
| 942 |
_2ddc _cEBK |
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| 999 |
_c85049 _d85049 |
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