Studies on Arthritis and Joint Disorders [electronic resource] / edited by Maria Jose Alcaraz, Oreste Gualillo, Olga Sánchez-Pernaute.

Biomarkers of oxidative stress in joint diseases -- Regulation of T-cell functions by oxidative stress -- Nitric oxide and the respiratory chain in synovial cells and chondrocytes -- Adipokines, molecular players at the crossroad between inflammation and oxidative stress. Role in arthropathies -- Regulation of cartilage and bone metabolism by oxidative stress -- Role of oxidative stress in bone aging -- Genetic Component of Oxidative Stress in Rheumatoid Arthritis -- Oxidative stress in rheumatoid arthritis -- Oxidative stress and premature atherosclerosis in RA -- Role of Oxidative Stress and Reactive Oxygen Radicals in the Pathogenesis of Systemic Sclerosis -- Antioxidant and anti-inflammatory properties of heme oxygenase-1 in osteoarthritic articular cells -- Oxidative stress at the crossroads between osteoarthritis and metabolic syndrome -- Metabolic syndrome and gout -- Natural Antioxidants in the pharmacological treatment of rheumatic immune and inflammatory diseases -- Antioxidants in the treatment of osteoarthritis and bone mineral loss -- Anti-cytokine agents to combat oxidative stress -- Oxidative Conditioning and treatment for Osteoarthritis -- The role of sirtuins in arthritis -- MicroRNA molecules, master regulators, biomarkers and potential therapies -- Estrogen-dependent transcriptional activity, a protection against ROS in osteoarthritis.

Joint diseases are a major public health concern. Reactive oxygen species are mediators in pathways associated with joint tissue injury. Oxidative Stress in Applied Basic Research and Clinical Practice: Studies on Arthritis and Joint Disorders provides background to understanding the role of reactive oxygen species in joint diseases, as well as therapeutic strategies for their regulation. International experts discuss recent advances on experimental and clinical data focused on free radical-mediated mechanisms of disease. The book also addresses the protective role of antioxidants against the insult of reactive oxygen species in rheumatic diseases.