Systems Biology of Tuberculosis [electronic resource] / edited by Johnjoe McFadden, Dany J.V. Beste, Andrzej M. Kierzek.

Foreword -- Modeling Mycobacterium tuberculosis H37Rv in silico -- Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis -- Probing Gene Regulatory Networks to Decipher Host-Pathogen Interactions -- Metabolism of Mycobacterium tuberculosis -- Protein-protein interaction in the –omics era: Understanding Mycobacterium tuberculosis function -- A systems biology approach for understanding granuloma formation and function in tuberculosis -- Stochastic gene expression in bacterial pathogens: a mechanism for persistence? -- Drug Discovery -- Diagnosis -- Index.

Tuberculosis remains one of the world’s biggest killers responsible for more than a million deaths each year. New drugs and new vaccines are urgently needed to tackle the disease. This book describes the application of this century’s first new science, systems biology, to the study of tuberculosis. After introducing the basic principles of systems biology, successive chapters describe how systems-based approaches provide new insights into gene regulation, metabolism, protein-protein interaction, host-pathogen interactions, the immune response, persistence, drug treatment and diagnosis of tuberculosis. This book will be an invaluable aid to anyone interested in exploring how the latest science is helping us to understand this ancient disease.