Epigenetics and Complex Traits [electronic resource] / edited by Anna K. Naumova, Celia M.T. Greenwood.

Part I: Epigenetic phenomena in the germ line and early embryonic development and their effects on the inheritance of genetic traits -- Epigenetic reprogramming in the mammalian germ line -- Establishment of tissue-specific epigenetic states during development -- X-chromosome Inactivation -- Cis- and trans-effects underlying polar overdominance at the callipyge locus -- Transgenerational epigenetic effects and complex inheritance patterns -- Autosomal monoallelic expression -- Part II: Epigenetic variation in health and disease -- Recurrent CNVs in the etiology of epigenetic neurodevelopmental disorders -- Impact of the early-life environment on the epigenome and behavioral development -- Interaction between genetics and epigenetics in cancer -- Part III: Impact of epigenetics on complex trait genetics and analysis -- Epigenetic variation, phenotypic heritability, and evolution -- Statistical Approaches for Detecting Transgenerational Genetic Effects in Humans -- Transmission ratio distortion: a neglected phenomenon with many consequences in genetic analysis and population genetics -- Epigenome Wide Association Studies: Potential insights into human disease -- Analytical Considerations for Epigenome-wide Association Scans of Complex Traits -- Index.                             .

Epigenetics and Complex Traits provides an overview of basic epigenetic phenomena that influence transmission of genetic traits, including the pivotal roles of epigenetic factors in genome integrity, genetic transmission and phenotypic variation at critical developmental points, interactions between epigenetic marks and genetic variation, as well as a detailed examination of how epigenetic considerations can alter interpretation and analysis of risks for complex traits.   Included in this book are several overviews of the impact of inter-individual variation in epigenetic states, from major changes that cause congenital developmental defects to subtle changes and their impact on complex traits. In addition, there are chapters examining the relationship between epigenetic changes and genetic changes in human disease, methods for statistical analysis of epigenetics effects in human disease genetic studies or in population genetics, and a consideration of how epigenetics influences inheritance and analysis of inheritance.   Epigenetics and Complex Traits is a  resource for those who are working in mammalian genetics or analysis of human genetic data and are interested in the impact of epigenetics on inheritance.                                      .